A Coenzyme‐Based Deep Eutectic Supramolecular Polymer Bioadhesive

α-lipoic acid (LA), a coenzyme, has proved to have excellent antioxidant and antibacterial activities; however, its intrinsic hydrophobicity metastability of polyLA remains major challenge for the application LA-based bulk materials in biomedical field. Herein, self-stabilized deep eutectic supramolecular polymer (LA-DESP) adhesive is created by one-step heating mixture LA sodium α-lipoate (LA-Na) (S-, R-isomer, racemate) without introducing any exogenous stabilizing molecules. The underlying effect LA/LA-Na unveiled be originated from multiple hydrogen bonds between polyLA-Na, which not only prevent depolymerization but also lower melting point LA-DESP near body pathological temperature. Copolymerization LA-Na slows down dissociation thus affording sustainable release bioactive small molecules satisfactory functions. Also, exhibits fast tough adhesion diverse substrates, including wet tissues, relying on situ curing property rich carboxyl groups. explored as tissue sealant, can well replace surgical suture enhance wound healing skin incision rat model. unprecedented will provide new strategy development bioadhesives.